La Jolla Mom
Columbia, where you’ll find most of downtown's tallest buildings and a lot of the waterfront attractions like the USS Midway Museum and the Maritime Museum.
The Core neighborhood is the heart of San Diego’s government, as well as a commercial center with some great shopping.
Cortez Hill is quieter and mostly residential, though it’s also the home of the historic (and notably tall) El Cortez hotel.
The Gaslamp Quarter was the birthplace of downtown and is the epicenter of nightlife in San Diego. Many choose to stay in Gaslamp San Diego hotels for this reason.
Little Italy was originally home to scores of fishers from Italy but is now one of the city’s go-to areas for the best food and drink.